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Molecular basis of thalassemia syndromes in Serbia: an update
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: Thalassemia syndromes are heterogeneous group of hereditary anemias characterized
by defects in the synthesis of hemoglobin (Hb) polypeptide chains. These disorders comprise thalassemias and thalassemic ...
Sugars and their substitutes increase pathogenicity of Pseudomonas aeruginosa
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: Differentsugars are commonly used in the diet, but little is understood about the various
effects of human health that they can affect. Hence, the impact of sugars and their substitutes used in
diet on the ...
Reconstitution of non-carrier, heterozygous and homozygous prothrombin belgrade mutation carrier plasma using recombinant proteins
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: The prothrombin Belgrade variant (c.1787G>A, p.Arg596Gln) is a rare mutation found in
Serbia, Japan, China, America, India and leads to antithrombin resistance. Prothrombin Belgrade mutation influencesthro ...
Expression profiles of long non-coding RNA gas5 and microrna-222 in younger AML patients
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: Acute myeloid leukemia (AML) is a heterogeneous malignant disease, that accounts for
80% of all acute leukemias in adults. Imprecise risk stratification and lack of personalized treatment creates a constant ...
Two main skeletal muscle molecular phenotypes of mouse dm1 models: a comparative transcriptomic analysis
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction:Myotonic dystrophy type 1 (DM1) is a rare, incurable multisystemic disease, with the main
symptoms being skeletal muscle weakness, atrophy, and myotonia. It is caused by CTG expansion in the
3' UTR of the ...
Identification of potentally causal variants for myasthenia gravis: a bioinformatics-driven fine-mapping approach combined with genetic association study
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: Genome-wide association studies (GWAS) identify genomic loci that contain genetic determinants
of complex diseases. Subsequent functional genomic approaches, such as bioinformatic finemapping
and ...
E-cigarette liquid and condensate leads to impaired embryonic development of zebrafish
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: E-cigarettes are advertised as safer alternative to tradicional cigarettes. However, they
contain chemicals that can exhibit toxic effects on the organism. Notably, effects of e-cigarettes on in
utero ...
Transcriptional profiling of PHF19 gene in colon cancer cell lines cultivated in 3D
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: A recent comprehensive pan-cancer transcriptome analysis revealed differential activity
of two alternative promoters of the gene PHF19 in malignant and non-malignant gut mucosa. Transcription from the promoter ...
Bacterial nanocellulose – new beginning for end-of-life plastics
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: Fossil-based polymers continue to be widely used despite their negative environmental
impact. Bioplastics, such as polylactic acid (PLA), offer a promising alternative as they are derived from
renewable ...
Application of CRISPR/cas9 technology for in vitro disease modelling in glycogen storage disease type IB
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: Glycogen storage disease type Ib (GSD-Ib) is an autosomal recessive disorder characterized by fasting hypoglycemia and the accumulation of glycogen in the liver, kidneys and intestinal mucosa. Recent studies ...