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Now showing items 11-20 of 20
Application of CRISPR/cas9 technology for in vitro disease modelling in glycogen storage disease type IB
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: Glycogen storage disease type Ib (GSD-Ib) is an autosomal recessive disorder characterized by fasting hypoglycemia and the accumulation of glycogen in the liver, kidneys and intestinal mucosa. Recent studies ...
In vitro and in vivo anticancer action of Saquinavir-NO, a novel nitric oxide-derivative of the protease inhibitor saquinavir, on hormone resistant prostate cancer cells
(Taylor & Francis Inc, Philadelphia, 2011)
The NO-derivative of the HIV protease inhibitor saquinavir (Saq-NO) is a nontoxic variant of the parental drug with enhanced anticancer activity on several cell lines. However, it is still unclear whether the p53 status ...
Multiple antimelanoma potential of dry olive leaf extract
(Wiley, Hoboken, 2011)
Various constituents of the olive tree (Olea europaea) have been traditionally used in the treatment of infection, inflammation, prevention of chronic diseases, cardiovascular disorders and cancer. The anticancer potential ...
ALPHA-1 Antitrypsin Affects U0126-Induced Cytotoxicity in Colon Cancer Cell Line (HCT116)
(Maik Nauka/Interperiodica/Springer, New York, 2016)
Alpha-1-antitrypsin (AAT), an acute phase protein, is the principal circulatory anti-protease. This multifunctional protein is encoded by the SERPINA1 gene. Although AAT was recognised as a potential tumour marker, its ...
New polyene macrolide family produced by submerged culture of Streptomyces durmitorensis
(Nature Publishing Group, London, 2011)
A new polyene macrolide family, closely related to the pentaene macrolide antibiotic roflamycoin, was isolated from the both fermentation broth and biomass of Streptomyces durmitorensis wild-type strain MS405. The main ...
Molekularna osnova hronične limfocitne leukemije : korelacija između mutacionog statusa teških lanaca imunoglobulina i ekspresije apoptotskih gena / Molecular basis of chronic lymphocytic leukemia: correlation between the immunoglobulin heavy chain mutational status and the expression of apoptotic genes
(Univerzitet u Beogradu, Biološki fakultet, 2012)
Hronična limfocitna leukemija (HLL), najčešći tip leukemije u Evropi i Severnoj Americi, se manifestuje kao klonska ekspanzija zrelih CD5+ CD19+ CD23+ sIgM+/- B limfocita i karakteriše se izuzetno heterogenim kliničkim ...
Crosstalk between Glycogen-Selective Autophagy, Autophagy and Apoptosis as a Road towards Modifier Gene Discovery and New Therapeutic Strategies for Glycogen Storage Diseases
(MDPI, Basel, 2022)
Glycogen storage diseases (GSDs) are rare metabolic monogenic disorders characterized by an excessive accumulation of glycogen in the cell. However, monogenic disorders are not simple regarding genotype-phenotype correlation. ...
Udruženost ekspresije Bax gena i Bcl2/Bax odnosa sa kliničkim i molekularnim prognostičkim markerima u hroničnoj limfocitnoj leukemiji / Association of Bax expression and Bcl2/Bax ratio with clinical and molecular prognostic markers in chronic lymphocytic leukemia
(Društvo medicinskih biohemičara Srbije, Beograd i Versita, 2016)
Uvod: Rezistencija na apoptozu koja karakteriše maligne B limfocite in vivo u hroničnoj limfocitnoj leukemiji (HLL) delimično je uzrokovana unutrašnjim poremecajima apoptotske mašinerije u ovim celijama. Ti poremecaji su ...
Analiza ekspresije i uloge humanog gena SOX14 u neuralnoj diferencijaciji in vitro i regulaciji malignog fenotipa / Analysis of the expression and role of the human gene SOX14 in neural differentiation in vitro and in the regulation of malignant phenotype
(Univerzitet u Beogradu, Biološki fakultet, 2018)
Visok stepen očuvanosti tokom evolucije i činjenica da do danas nije opisan nijedan klinički sindrom povezan sa mutacijama u genu SOX14, ukazuju na značajnu ulogu ovog gena tokom embrionalnog razvića. Iako je prošlo dvadeset ...
An updated pharmacological insight into calotropin as a potential therapeutic agent in cancer
(Frontiers in Pharmacology, 2023)
Calotropin is a pharmacologically active compound isolated from milkweed plants like Calotropis procera, Calotropis gigantea, and Asclepias currasavica that belong to the Asclepiadaceae family. All of these plants are ...