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Prikaz rezultata 11-20 od 110
Profiling Pre-Replication Complex Mutations in Cancer
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
The pre-replication complex (preRC) consists of 15 proteins that mark DNA replication
initiation sites and regulate replication timing. Deficiency in preRC proteins results in
genomic instability (re-replication) and ...
Dehydrins in the service of protecting the DNA helix from the aspect of molecular dynamics (MD)
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Drought stress is one of the greatest threats to global food security, posing a major challenge
to agriculture. Understanding the molecular mechanisms underlying desiccation tolerance
in resurrection plants like Ramonda ...
Clustering and classification of SARS-COV-2 isolates using RSCU
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
The existence of a large number of sequenced SARS-COV-2 isolates provides an
opportunity to observe genomic variability in a massive sample. The goal of our research
was to use data mining techniques to study possible ...
Decoding Cystic Fibrosis Phenotype
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Cystic fibrosis (CF) is a monogenic autosomal recessive disease caused by mutations in
transmembrane conductance regulator (CFTR) gene. The golden standard for the diagnosis
of CF is sweat chloride testing (>60 mmol/L) ...
Machine learning approach in inferring main population-level COVID-19 risk factors
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Machine-learning methods have become indispensable in scientific research as the
amount of available data has grown exponentially in recent years. It is, thus, necessary
to employ various unsupervised and supervised ...
Application of classification algorithms for hip implant surface topographies
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Experimental studies have shown that lower shear stress values lead to better femoral
bone – hip implant connection. Numerical simulations have provided option to reduce
the number of experimental studies through analysis ...
Complexity driven evolution of Alternative splicing
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Based on the animal model of agonistic interactions, we observed co-varied (linked)
alternative exons (LEs) in the genes with alternative splicing phenotype in brain. As a result,
we have found 263 positively co-varied ...
Comparative study of in silico protein design techniques
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Protein design plays a pivotal role in various scientific and industrial applications, such
as drug development and biotechnology. With the advancement of computational
methods, new tools and algorithms have emerged to ...
Shotgun metagenomics reveals gut microbiota features associated with the efficacy of myeloid derived suppressor cells in the prevention of neuroinflammation
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Although genetic predisposition to Multiple Sclerosis (MS) may play an essential role in disease
development, myeloid cell overactivation and gut microbiota dysbiosis are key contributors to MS
pathogenesis. Myeloid-Derived ...
Methodology, performance and retrainability survey of intrinsic disorder predictors
(Belgrade : Institute of molecular genetics and genetic engineering, 2023)
Intrinsically disordered proteins and regions are widely distributed within most proteomes.
Recent studies show that they are associated with many essential biological processes
and a broad range of human diseases. Given ...